Amflee 402mg (40-60 kg) Very Large Dog, with Fipronil against fleas and ticks X 10 Pipettes

Regular price €89,80

Treatment of flea (Ctenocephalides spp.) and tick (Dermacentor reticulatus) infestations.

For treatment of Trichodectes canis biting lice infestations on dogs. Most lice are killed within 2 days.

Insecticidal efficacy against new infestations with adult fleas persists for up to 8 weeks.

The product has a persistent acaricidal efficacy for up to 3 weeks against Ixodes ricinus and up to 4 weeks against Rhipicephalus sanguineus and Dermacentor reticulatus. If ticks of some species (Ixodes ricinus, Rhipicephalus sanguineus) are present when the product is applied, all the ticks may not be killed within the first 48 hours.

The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD) where this has been previously diagnosed by a veterinary surgeon.


Amounts to be administered and administration route


Route of administration and dosage:

External use only.

Administer by topical application to the skin according to the bodyweight as follows:

1 pipette of 1.34 ml per dog weighing over 10 kg and up to 20 kg bodyweight.


Method of administration:

Remove the pipette from the triplex bag. Hold the pipette in an upright position, twist and pull the cap off. Turn the cap around and place the other end of the cap back on the pipette. Push and twist the cap to break the seal, then remove the cap from the pipette. Spread the animal hairs in the area between the shoulder blades to make the skin visible. Put the tip of the pipette onto the skin and press the unit-dose pipette several times to empty its contents directly onto the skin at one or two spots.


It is important to make sure that the product is applied to an area where the animal cannot lick it off, and to make sure that animals do not lick each other following treatment.

The hair should be parted and the product applied to the skin. Temporary changes to the coat (clumped/greasy hair and/or deposits on the hair) may be noted at the application site.


Treatment schedule:

For optimal control of flea and/or tick infestation the treatment schedule can be based on the local epidemiological situation.

In the absence of safety studies, the minimum treatment interval is 4 weeks.



Amount pipettes



2 kg to 10 kg

1 pipet

Amflee 67

0,67 ml

67 mg

10 kg to maximal 20 kg

1 pipet

Amflee 134

1,34 ml

134 mg

20 kg to 40 kg

1 pipet

Amflee 268

2, 68 ml

268 mg

40 kg to 60 kg

1 pipet

Amflee 402

4,02 ml

402 mg

over 60 kg

1 pipet Amflee 402 + smaller pipet

4,02 ml + suitable combination

402 mg + suitable combination


AMFLEE is available in:

3 Pipettes

6 Pipettes

30 Pipettes


Bathing/immersion in water within two days after application of the product should be avoided. After weekly immersions in water for one minute the period of persistent insecticidal efficacy against fleas was 7 weeks.


The product does not prevent ticks from attaching to the animals. If the animal has been treated prior to exposure to the ticks, the ticks will be killed in the first 24-48 hours after attachment. This will usually be prior to engorgement, minimising but not excluding the risk of transmission of diseases. Once dead, ticks will often drop off the animal, but any remaining ticks may be removed with a gentle pull.


Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.


When used as part of a strategy for the treatment of flea Allergy Dermatitis, monthly applications to the allergic patient and to other dogs in the household are recommended.


For optimal control of flea infestation in multi-pet household, all dogs and cats in the household should be treated with a suitable insecticide.




Do not use on puppies less than 2 months old and/or weighing less than 2 kg in the absence of available data.

Do not use on sick (e.g. systemic diseases, fever…) or convalescent animals.

Do not use in rabbits, as adverse reactions and even death could occur.

This product is specifically developed for dogs. Do not use in cats, as this could lead to overdosing.

Do not use in cases of hypersensitivity to the active substance, dimethyl sulphoxide or to any of other excipients.


Special precautions for use


i) Special precautions for use in animals


Animals should be weighed accurately prior to treatment.


Avoid contact with the animal's eyes. In the case of accidental eye contact, immediately and thoroughly flush the eyes with water.


It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment.


Do not apply the product on wounds or damaged skin.


ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals


This product can cause mucous membrane and eye irritation. Therefore, contact between the product and the mouth or eyes should be avoided.

In the case of accidental eye contact immediately and thoroughly flush the eyes with water. If eye irritation persists seek medical advice and show the package leaflet or the label to the physician.

Do not smoke, drink or eat during application.

Avoid contents coming into contact with the fingers. If this occurs, wash off immediately with soap and water.

Wash hands after use.

People with a known hypersensitivity to fipronil or dimethyl sulphoxide or other excipients should avoid contact with the veterinary medicinal product.

Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that 

recently treated animals should not be allowed to sleep with owners, especially children.

Keep pipettes in the original packaging and dispose of used pipettes immediately.


iii) Other precautions


Fipronil may adversely affect aquatic organisms. Dogs should not be allowed to swim in water courses for 2 days after application.


Adverse reactions (frequency and seriousness)


If licking occurs, a brief period of hypersalivation may be observed.

Among the extremely rare suspected adverse reactions, transient cutaneous reactions on the application site (skin discoloration, local alopecia, pruritus, erythema) and general pruritus or alopecia have been reported after use. Exceptionally, hypersalivation, reversible neurologic symptoms (hyperesthesia, depression, nervous symptoms), vomiting or respiratory symptoms have been observed after use.